Whipple's disease is a malabsorption illness. It interferes with the body's ability to absorb certain nutrients. The disease causes weight loss, incomplete breakdown of carbohydrates or fats, and malfunctions of the immune system, and it may affect the heart, lungs, brain, and eyes. When recognized and treated, Whipple's disease can usually be cured. Untreated, the disease may be fatal. 
 
Whipple's disease is caused by bacteria named Tropheryma whippelii. It can affect any system of the body, but occurs most often in the small intestine. Lesions appear on the wall of the small intestine and thicken the tissue. The villi – tiny, finger-like protrusions from the wall that help absorb nutrients – are damaged. 

Symptoms include diarrhea, intestinal bleeding, abdominal pain, loss of appetite, weight loss, fatigue, and weakness. Arthritis and fever often occur several years before intestinal symptoms develop. Patients may experience neurological symptoms as well. Diagnosis is based on symptoms and the results of a biopsy of tissue from the small intestine. 

Whipple's disease is treated with antibiotics to destroy the bacteria that cause the disease. The physician may use a number of different types, doses, and schedules of antibiotics to find the best treatment. Depending on the seriousness of the disease, treatment may also include fluid and electrolyte replacement. Electrolytes are salts and other substances in body fluid that the heart and brain need to function properly. Extra iron, folate, vitamin D, calcium, and magnesium may also be given to help compensate for the vitamins and minerals the body cannot absorb on its own. 

Full recovery of the small intestine may take up to 2 years, but the symptoms usually disappear in less time. Because relapse is common even after successful treatment, the health care team may continue to monitor the patient for many years.

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National Organization for Rare Disorders Inc. (NORD)